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What Is Detrol La

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What Is Detrol La
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Related post: Dredates the first opportunistic infection. 18-41 PHS 6040 (Rev. 1/83) GPO 895-100 DEPARTMENT Detrol La Coupons OF HEALTH AND HUMAN SERVICES • PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER Zm AI 003^1-01 LCI PERIOD COVERED October 1, 1982 to September 30, 1983 TITLE OF PROJECT (80 character$ or leM. Title must fit on one line between the borders.) Immunologic Alterations Which Correlate Detrol La Cost With Ijronunos oppression In AIDS PRINCIPAL INVESTIGATOR (Litt other professional personnel on subsequent pages.) (Nan\e. title, laboratory, and Institute affiliation) Thomas C. Quinn, Senior Investigator, LCI/NIAID COOPERATING UNITS (if any) Johns Hopkins University School of Medicine LAB/BRANCH Laboratory of Clinical Investigation Clinical Immunology INSTITUTE AND LOCATION NIAID. NIH Bethesda. MarylanH ?n?OR TOTAL MANYEARS: PROFESSIONAL: 0.3 0.3 CHECK APPROPRIATE BOX(ES) fXI (a) Human subjects CZ! (a1) Minors □ (a2) Interviews (b) Human tissues □ (c) Neither OMMABX OF WOBK. (Use. standard unreduced type, po not excjied the space provided,). , ^. . , A common denominator of patients with the acquired immune deficiency syndrome (AIDS) appears to be a broad spectrum of immune deficiencies. However, it is clear that we continue to lack the full understanding of the mechanism (s) responsible for this immuno- logic dysfunction. We have initiated a study to examine whether peripheral blood lymphocy :es from AIDS patients evidence a pattern of in vitro CMI response against mitogens and against specific viral antigens (CMV, HSV, BKV), in relation to disease progression, in vivo data generated by skin testing, and data generating by enumeration of T cell subsets as observed over a period of time. The ability to reconstitute the in vitro CMI response to specific viral antigens and mitogens will be measured by treatment with biologic modifiers such as IL-1, IL-2 and other lymphokines. Lastly, plasma from AIDS patients is examined to deterr whether it contains immunosuppressive factors to normal T lymphocytes in the above assays], and whether these factors can be modified or detected through plasmaphoresis. In preliminary studies, 10 homosexual men with lymphadenopathy and 10 homosexual men with AIDS have been studied longitudinally. AIDS patients (8 with opportunistic infection and two with Kaposi's sarcoma) and all lymphadenopathy patients were skin test anergic, had reversed T helper/T suppressor cell ratios with prominent T helper cell depletion, and demonstrated hypergammaglobulinemia and elevated immune complexes. Healthy homosexual men and patients with lymphadenopathy responded to pokeweed mitogen and viral antigens in lympholcyte transformation studies Detrol La Coupon and these responses were enhanced to control levels with the addition of interleukin-2. Significantly, lymphadenopathy patients lacked the ability to produce lymphokine -leukocyte migration inhibition factor (LIF) following antigen stimulation. This latter finding correlated with in vivo anergy in all Detrol La 4 Mg instances. Patients with AIDS demon- strated a marked reduction in lymphocyte transformation response to pokeweek mitogen and a total absence of responsiveness to viral antigen. Lymphocyte transformation was partially restored by interleukin-2 in this latter instance. However, Detrol La 2mg the ability to restore antigen induced responsiveness by IL-2 markedly decreased with disease progression, and lymphokine production remained negative. These data thus far demonstrate a Detrol La 4mg gradient of immune dysfunction that develops in AIDS and further study is warranted in regards to the exact nature of the immunosuppressive factors and their effect on immune regulation as measured hy lymphokine IL-1 and IL^2. PHS 6040 (Rev. 1/83) 18^2 GPO 895-100 DEPARTMENT OF HEALTH AND HUMAN What Is Detrol La SERVICES - PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER ZOl AI 00379-01 LCI PERIOD COVERED October 1, 1982 to September 30, 1983 TITLE OF PROJECT (80 characters or Detrol La Caps less. Title must fit on one line between the borders.) Studies of DNA Viruses and Other Possible Agents in AIDS Patients PRINCIPAL INVESTIGATOR (List other professional personnel on subsequent pages.) (Name, title, laboratory, and institute affiliation) S.E. Straus, Senior Investigator, LCI, NIAID COOPERATING UNITS (if any) G. Armstrong and G. Quinnan (BOB/FDA), H. Masur (CC, NIH), C. Lane and A.S. Fauci (LIR, NIAID), and P. Howley (NCI, NIH) LAB/BRANCH Laboratory of Clinical Investigation SECTION Medical Virology Section INSTITUTE AND LOCATION NIAID, NIH, Bethesda, MD 20205 TOTAL MANYEARS: 2.5 PROFESSIONAL: 1.5 OTHER: 1.0 CHECK APPROPRIATE BOX(ES) ED (a) Human subjects
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