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18-41
PHS 6040 (Rev. 1/83)
GPO 895-100
DEPARTMENT Detrol La Coupons OF HEALTH AND HUMAN SERVICES • PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
Zm AI 003^1-01 LCI
PERIOD COVERED
October 1, 1982 to September 30, 1983
TITLE OF PROJECT (80 character$ or leM. Title must fit on one line between the borders.)
Immunologic Alterations Which Correlate Detrol La Cost With Ijronunos oppression In AIDS
PRINCIPAL INVESTIGATOR (Litt other professional personnel on subsequent pages.)
(Nan\e. title, laboratory, and Institute affiliation)
Thomas C. Quinn, Senior Investigator, LCI/NIAID
COOPERATING UNITS (if any)
Johns Hopkins University School of Medicine
LAB/BRANCH
Laboratory of Clinical Investigation
Clinical Immunology
INSTITUTE AND LOCATION
NIAID. NIH Bethesda. MarylanH ?n?OR
TOTAL MANYEARS:
PROFESSIONAL:
0.3
0.3
CHECK APPROPRIATE BOX(ES)
fXI (a) Human subjects
CZ! (a1) Minors
□ (a2) Interviews
(b) Human tissues
□ (c) Neither
OMMABX OF WOBK. (Use. standard unreduced type, po not excjied the space provided,). , ^. . ,
A common denominator of patients with the acquired immune deficiency syndrome
(AIDS) appears to be a broad spectrum of immune deficiencies. However, it is clear that
we continue to lack the full understanding of the mechanism (s) responsible for this immuno-
logic dysfunction. We have initiated a study to examine whether peripheral blood lymphocy :es
from AIDS patients evidence a pattern of in vitro CMI response against mitogens and against
specific viral antigens (CMV, HSV, BKV), in relation to disease progression, in vivo data
generated by skin testing, and data generating by enumeration of T cell subsets as observed
over a period of time. The ability to reconstitute the in vitro CMI response to specific
viral antigens and mitogens will be measured by treatment with biologic modifiers such as
IL-1, IL-2 and other lymphokines. Lastly, plasma from AIDS patients is examined to deterr
whether it contains immunosuppressive factors to normal T lymphocytes in the above assays],
and whether these factors can be modified or detected through plasmaphoresis. In preliminary
studies, 10 homosexual men with lymphadenopathy and 10 homosexual men with AIDS have
been studied longitudinally. AIDS patients (8 with opportunistic infection and two with
Kaposi's sarcoma) and all lymphadenopathy patients were skin test anergic, had reversed T
helper/T suppressor cell ratios with prominent T helper cell depletion, and demonstrated
hypergammaglobulinemia and elevated immune complexes. Healthy homosexual men and
patients with lymphadenopathy responded to pokeweed mitogen and viral antigens in lympholcyte
transformation studies Detrol La Coupon and these responses were enhanced to control levels with the addition
of interleukin-2. Significantly, lymphadenopathy patients lacked the ability to produce
lymphokine -leukocyte migration inhibition factor (LIF) following antigen stimulation. This
latter finding correlated with in vivo anergy in all Detrol La 4 Mg instances. Patients with AIDS demon-
strated a marked reduction in lymphocyte transformation response to pokeweek mitogen
and a total absence of responsiveness to viral antigen. Lymphocyte transformation was
partially restored by interleukin-2 in this latter instance. However, Detrol La 2mg the ability to restore
antigen induced responsiveness by IL-2 markedly decreased with disease progression, and
lymphokine production remained negative. These data thus far demonstrate a Detrol La 4mg gradient of
immune dysfunction that develops in AIDS and further study is warranted in regards to the
exact nature of the immunosuppressive factors and their effect on immune regulation as
measured hy lymphokine IL-1 and IL^2.
PHS 6040 (Rev. 1/83)
18^2
GPO 895-100
DEPARTMENT OF HEALTH AND HUMAN What Is Detrol La SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl AI 00379-01 LCI
PERIOD COVERED
October 1, 1982 to September 30, 1983
TITLE OF PROJECT (80 characters or Detrol La Caps less. Title must fit on one line between the borders.)
Studies of DNA Viruses and Other Possible Agents in AIDS Patients
PRINCIPAL INVESTIGATOR (List other professional personnel on subsequent pages.)
(Name, title, laboratory, and institute affiliation)
S.E. Straus, Senior Investigator, LCI, NIAID
COOPERATING UNITS (if any)
G. Armstrong and G. Quinnan (BOB/FDA), H. Masur (CC, NIH),
C. Lane and A.S. Fauci (LIR, NIAID), and P. Howley (NCI, NIH)
LAB/BRANCH
Laboratory of Clinical Investigation
SECTION
Medical Virology Section
INSTITUTE AND LOCATION
NIAID, NIH, Bethesda, MD 20205
TOTAL MANYEARS:
2.5
PROFESSIONAL:
1.5
OTHER:
1.0
CHECK APPROPRIATE BOX(ES)
ED (a) Human subjects
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